Cyclization of Alkyne–Azide with Isonitrile/CO via Self-Relay Rhodium Catalysis

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• 作者：Zhen Zhang ; Fan Xiao ; Baoliang Huang ; Jincheng Hu ; Bin Fu ; Zhenhua Zhang
• 刊名：Organic Letters
• 出版年：2016
• 出版时间：March 4, 2016
• 年：2016
• 卷：18
• 期：5
• 页码：908-911
• 全文大小：399K
• ISSN：1523-7052

文摘

A self-relay rhodium(I)-catalyzed cyclization of alkyne–azides with two σ-donor/π-acceptor ligands (isonitriles and CO) to form sequentially multiple-fused heterocycle systems via tandem nitrene transformation and aza-Pauson–Khand cyclization has been developed. In this approach, an intriguing chemoselective insertion process of isonitriles superior to CO was observed. This reaction provides an alternative strategy to synthesize functionalized pyrrolo[2,3-b]indole scaffolds.