Copper-Mediated Direct Aryloxylation of Benzamides Assisted by an N,O-Bidentate Directing Group

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• 作者：Xin-Qi Hao ; Li-Juan Chen ; Baozeng Ren ; Liu-Yan Li ; Xin-Yan Yang ; Jun-Fang Gong ; Jun-Long Niu ; Mao-Ping Song
• 刊名：Organic Letters
• 出版年：2014
• 出版时间：February 21, 2014
• 年：2014
• 卷：16
• 期：4
• 页码：1104-1107
• 全文大小：379K
• ISSN：1523-7052

文摘

Copper-mediated selective mono- or diaryloxylation of benzamides has been achieved by using 2-aminopyridine 1-oxide as a new and removable N,O-bidentate directing group. The reaction system shows a broad substrate scope and provides a straightforward way for the synthesis of mono- and diaryloxylated benzoic acids.