Orthogonal Modification of Norbornene-Functional Degradable Polymers

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• 作者：Rebecca J. Williams ; Ian A. Barker ; Rachel K. O鈥橰eilly ; Andrew P. Dove
• 刊名：ACS Macro Letters
• 出版年：2012
• 出版时间：November 20, 2012
• 年：2012
• 卷：1
• 期：11
• 页码：1285-1290
• 全文大小：331K
• 年卷期：v.1,no.11(November 20, 2012)
• ISSN：2161-1653

文摘

Well-defined norbornene-functional poly(carbonate)s were prepared by ring-opening polymerization and utilized as multireactive polymeric scaffolds in a range of postpolymerization modifications. The norbornene-functional handles were shown to undergo facile reaction with azides via a 1,3-dipolar cycloaddition, tetrazines in the inverse electron demand Diels鈥揂lder reaction and thiols via radical thiol-ene coupling. Furthermore, the above-mentioned chemistries were demonstrated in a sequential one-pot, three-step modification reaction illustrating the potential of these polymers as scaffolds to access multifunctionalized materials in an undemanding manner.