Surface Analysis under Ambient Conditions Using Plasma-Assisted Desorption/Ionization Mass Spectrometry

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• 作者：Lucy V. Ratcliffe ; Frank J. M. Rutten ; David A. Barrett ; Terry Whitmore ; David Seymour ; Claire Greenwood ; Yolanda Aranda-Gonzalvo ; Steven Robinson ; Martin McCoustra
• 刊名：Analytical Chemistry
• 出版年：2007
• 出版时间：August 15, 2007
• 年：2007
• 卷：79
• 期：16
• 页码：6094 - 6101
• 全文大小：332K
• 年卷期：v.79,no.16(August 15, 2007)
• ISSN：1520-6882

文摘

A novel plasma-assisted desorption/ionization (PADI)method that can be coupled with atmospheric pressuresampling mass spectrometry to yield mass spectral information under ambient conditions of pressure and humidity from a range of surfaces without the requirement forsample preparation or additives is reported. PADI iscarried out by generating a nonthermal plasma whichinteracts directly with the surface of the analyte. Desorption and ionization then occur at the surface, and ions aresampled by the mass spectrometer. The PADI techniqueis demonstrated and compared with desorption electrospray ionization (DESI) for the detection of active ingredients in a range of over-the-counter and prescriptionpharmaceutical formulations, including nonsterodial anti-inflammatory drugs (mefenamic acid, Ibugel, and ibuprofen), analgesics (paracetamol, Anadin Extra), and Beecham's "all in one" cold and flu remedy. PADI has alsobeen successfully applied to the analysis of nicotine intobacco and thiosulfates in garlic. PADI experiments havebeen performed using a prototype source interfaced witha Waters Platform LCZ single-quadrupole mass spectrometer with limited modifications and a Hiden AnalyticalHPR-60 molecular beam mass spectrometer (MBMS).The ability of PADI to rapidly detect active ingredients inpharmaceuticals without the need for prior sample preparation, solvents, or exposed high voltages demonstratesthe potential of the technique for high-throughput screening in a pharmaceutical or forensic environment.