Allylic Oxidation of Alkenes Catalyzed by a Copper鈥揂luminum Mixed Oxide

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• 作者：Ana Leticia Garc铆a-Cabeza ; Rub茅n Mar铆n-Barrios ; F. Javier Moreno-Dorado ; Mar铆a J. Ortega ; Guillermo M. Massanet ; Francisco M. Guerra
• 刊名：Organic Letters
• 出版年：2014
• 出版时间：March 21, 2014
• 年：2014
• 卷：16
• 期：6
• 页码：1598-1601
• 全文大小：311K
• 年卷期：v.16,no.6(March 21, 2014)
• ISSN：1523-7052

文摘

A strategy for the allylic oxidation of cyclic alkenes with a copper鈥揳luminum mixed oxide as catalyst is presented. The reaction involves the treatment of an alkene with a carboxylic acid employing tert-butyl hydroperoxide as the oxidant. In all cases, the corresponding allylic esters are obtained. When l-proline is employed, the allylic alcohol or ketone is obtained. The oxidation of cyclohexene and valencene has been optimized by design of experiments (DoE) statistical methodology.