Direct, Regioselective, and Chemoselective Preparation of Novel Boronated Tryptophans by Friedel鈥揅rafts Alkylation

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• 作者：Silvia Bartolucci ; Francesca Bartoccini ; Marika Righi ; Giovanni Piersanti
• 刊名：Organic Letters
• 出版年：2012
• 出版时间：January 20, 2012
• 年：2012
• 卷：14
• 期：2
• 页码：600-603
• 全文大小：300K
• 年卷期：v.14,no.2(January 20, 2012)
• ISSN：1523-7052

文摘

A facile synthetic approach to the direct preparation of various novel unnatural boronated protected tryptophans using a regio- and chemoselective electrophilic substitution of 4- and 5-boronated indoles with N-protected dehydroalanine is described. The gram-scale synthesis of two free tryptophan boronic acids is also reported.