Fluorine End-Capped Optical Fibers for Photosensitizer Release and Singlet Oxygen Production

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• 作者：Dorota Bartusik ; David Aebisher ; Goutam Ghosh ; Mihaela Minnis ; Alexander Greer
• 刊名：The Journal of Organic Chemistry
• 出版年：2012
• 出版时间：May 18, 2012
• 年：2012
• 卷：77
• 期：10
• 页码：4557-4565
• 全文大小：394K
• 年卷期：v.77,no.10(May 18, 2012)
• ISSN：1520-6904

文摘

The usefulness of a fiber optic technique for generating singlet oxygen and releasing the pheophorbide photosensitizer has been increased by the fluorination of the porous Vycor glass tip. Singlet oxygen emerges through the fiber tip with 669-nm light and oxygen, releasing the sensitizer molecules upon a [2 + 2] addition of singlet oxygen with the ethene spacer and scission of a dioxetane intermediate. Switching from a nonfluorinated to a fluorinated glass tip led to a clear reduction of the adsorbtive affinity of the departing sensitizer with improved release into homogeneous toluene solution and bovine tissue, but no difference was found in water since the sensitizer was insoluble. High surface coverage of the nonafluorohexylsilane enhanced the cleavage efficiency by 15% at the ethene site. The fluorosilane groups also caused crowding and seemed to reduce access of ¹O₂ to the ethene site, which attenuated the total quenching rate constant k_T, although there was less wasted ¹O₂ (from surface physical quenching) at the fluorosilane-coated than the native SiOH silica. The observations support a quenching mechanism that the replacement of the SiOH groups for the fluorosilane C鈥揌 and C鈥揊 groups enhanced the ¹O₂ lifetime at the fiber tip interface due to less efficient electronic-to-vibronic energy transfer.