Increased Salicylate Concentrations in Urine of Human Volunteers after Consumption of Cranberry Juice

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• 作者：Garry G. Duthie ; Janet A. M. Kyle ; Alison McE. Jenkinson ; Susan J. Duthie ; Gwen J. Baxter ; and John R. Paterson
• 刊名：Journal of Agricultural and Food Chemistry
• 出版年：2005
• 出版时间：April 20, 2005
• 年：2005
• 卷：53
• 期：8
• 页码：2897 - 2900
• 全文大小：44K
• 年卷期：v.53,no.8(April 20, 2005)
• ISSN：1520-5118

文摘

The aim of this study was to assess whether regular consumption of cranberry juice results inelevations in urinary salicylate concentrations in persons not taking salicylate drugs. Two groups ofhealthy female subjects (11/group) matched for age, weight, and height consumed 250 mL of eithercranberry juice or a placebo solution three times a day (i.e., 750 mL/day) for 2 weeks. At weeklyintervals, salicylic acid and salicyluric acid (the major urinary metabolite of salicylic acid) concentrationswere determined in urine by HPLC with electrochemical detection. Concentrations of salicylic acid inplasma were also determined. Consumption of cranberry juice was associated with a marked increase(p < 0.001) of salicyluric and salicylic acids in urine within 1 week of the intervention. After 2 weeks,there was also a small but significant (p < 0.05) increase in salicylic acid in plasma. The regularconsumption of cranberry juice results in the increased absorption of salicylic acid, an anti-inflammatorycompound that may benefit health.Keywords: Salicylic acid; salicyluric acid; cranberry juice; salicylates