Mild Pd-Catalyzed N-Arylation of Methanesulfonamide and Related Nucleophiles: Avoiding Potentially Genotoxic Reagents and Byproducts

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• 作者：Brandon R. Rosen ; J. Craig Ruble ; Thomas J. Beauchamp ; Antonio Navarro
• 刊名：Organic Letters
• 出版年：2011
• 出版时间：May 20, 2011
• 年：2011
• 卷：13
• 期：10
• 页码：2564-2567
• 全文大小：757K
• 年卷期：v.13,no.10(May 20, 2011)
• ISSN：1523-7052

文摘

A convenient, general, and high yielding Pd-catalyzed cross-coupling of methanesulfonamide with aryl bromides and chlorides is reported. The use of this method eliminates concern over genotoxic impurities that can arise when an aniline is reacted with methanesulfonyl chloride. The application of this method to the synthesis of dofetilide is also reported.