Library Synthesis Using 5,6,7,8-Tetrahydro-1,6-naphthyridines as Scaffolds

详细信息    查看全文

• 作者：Ya Zhou ; Aaron B. Beeler ; Sanghyun Cho ; Yuehong Wang ; Scott G. Franzblau ; John K. Snyder
• 刊名：Journal of Combinatorial Chemistry
• 出版年：2008
• 出版时间：July 2008
• 年：2008
• 卷：10
• 期：4
• 页码：534 - 540
• 全文大小：166K
• 年卷期：v.10,no.4(July 2008)
• ISSN：1520-4774

文摘

The chemistry of 5,6,7,8-tetrahydro-1,6-naphthyridine scaffolds, synthesized by intramolecular cobalt-catalyzed [2 + 2 + 2] cyclizations, has been exploited for library synthesis. Urea, amide, and sulfonamide formations were used in the synthesis of a 101-membered library. Screening of the library for antituberculosis activity revealed three lead compounds.