Tandem Processes Identified from Reaction Screening: Nucleophilic Addition to Aryl N-Phosphinylimines Employing La(III)-TFAA Activation
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- 作者：Hidenori Kinoshita ; Oscar J. Ingham ; Winnie W. Ong ; Aaron B. Beeler ; John A. Porco ; Jr.
- 刊名：Journal of the American Chemical Society
- 出版年：2010
- 出版时间：May 12, 2010
- 年：2010
- 卷：132
- 期：18
- 页码：6412-6418
- 全文大小：515K
- 年卷期：v.132,no.18(May 12, 2010)
- ISSN：1520-5126
文摘
Reaction screening of nucleophilic reaction partners for addition to N-diphenylphosphinylimines employing lanthanum(III) triflate as a catalyst and trifluoroacetic anhydride (TFAA) as an activator is reported. A number of tandem processes leading to novel chemotypes including aza-Prins/intramolecular Friedel−Crafts annulations have been identified, and both reaction scope and mechanism further investigated.