Multidimensional Reaction Screening for Photochemical Transformations as a Tool for Discovering New Chemotypes

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• 作者：V茅ronique I. Martin ; John R. Goodell ; Oscar J. Ingham ; John A. Porco ; Jr. ; Aaron B. Beeler
• 刊名：Journal of Organic Chemistry
• 出版年：2014
• 出版时间：May 2, 2014
• 年：2014
• 卷：79
• 期：9
• 页码：3838-3846
• 全文大小：541K
• 年卷期：v.79,no.9(May 2, 2014)
• ISSN：1520-6904

文摘

We have developed an automated photochemical microfluidics platform that integrates a 1 kW high-pressure Hg vapor lamp and allows for analytical pulse flow or preparative continuous flow reactions. Herein, we will discuss the use of this platform toward the discovery of new chemotypes through multidimensional reaction screening. We will highlight the ability to discretely control wavelengths with optical filters, allowing for control of reaction outcomes.