Catalytic Enantioselective Decarboxylative Protonation

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• 作者：Justin T. Mohr ; Toyoki Nishimata ; Douglas C. Behenna ; Brian M. Stoltz
• 刊名：Journal of the American Chemical Society
• 出版年：2006
• 出版时间：September 6, 2006
• 年：2006
• 卷：128
• 期：35
• 页码：11348 - 11349
• 全文大小：56K
• 年卷期：v.128,no.35(September 6, 2006)
• ISSN：1520-5126

文摘

We report a highly enantioselective, general catalytic system for the facile synthesis of tertiary stereocenters by protonation adjacent to cyclic ketones. The method relies on catalytic decarboxylative protonation of readily accessible racemic quaternary -ketoesters. A range of substituted cycloalkanone compounds can be accessed through this process with high levels of enantioselectivity.