Diols, α-Ketols, and Diones as 22π Components in [2+2+2] Cycloadditions of 1,6-Diynes via Ruthenium(0)-Catalyzed Transfer Hydrogenation
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- 作者：Hiroki Sato ; Matthias Bender ; Weijie Chen ; Michael J. Krische
- 刊名：Journal of the American Chemical Society
- 出版年：2016
- 出版时间：December 21, 2016
- 年：2016
- 卷：138
- 期：50
- 页码：16244-16247
- 全文大小：451K
- ISSN：1520-5126
文摘
The first use of vicinal diols, ketols, or diones as 22π components in metal-catalyzed [2+2+2] cycloaddition is described. Using ruthenium(0) catalysts, 1,6-diynes form ruthenacyclopentadienes that engage transient diones in successive carbonyl addition. Transfer hydrogenolysis of the resulting ruthenium(II) diolate mediated by the diol or ketol reactant releases the cycloadduct with regeneration of ruthenium(0) and the requisite dione.