Bioactive Diterpenes from Orthosiphon labiatus and Salvia africana-lutea
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- 作者：Ahmed A. Hussein ; Jacobus J. M. Meyer ; Marí ; a L. Jimeno ; Benjamí ; n Rodrí ; guez
- 刊名：Journal of Natural Products
- 出版年：2007
- 出版时间：February 2007
- 年：2007
- 卷：70
- 期：2
- 页码：293 - 295
- 全文大小：53K
- 年卷期：v.70,no.2(February 2007)
- ISSN：1520-6025
文摘
The known (+)-trans-ozic acid (1) and two new labdane diterpenoids (2 and 3) have been isolated from an ethanolextract of Orthosiphon labiatus. The structures of 2 and 3 were established mainly by 1D and 2D NMR spectroscopicmeans. The ethanolic extract of Salvia africana-lutea afforded the known abietane diterpenoids carnosol (4), rosmadial(5), and carnosic acid (characterized as its derivative 6). Compounds 3 and 6 exhibited MICs of 157 and 28 
M,respectively, against Mycobacterium tuberculosis, while 2 and 6 showed cytotoxic activity with IC50 82 and 69 M,respectively, against a breast (MCF-7) human cancer cell line.
M,respectively, against Mycobacterium tuberculosis, while 2 and 6 showed cytotoxic activity with IC50 82 and 69 M,respectively, against a breast (MCF-7) human cancer cell line.