Organically Modified Silica Nanoparticles with Covalently Incorporated Photosensitizer for Photodynamic Therapy of Cancer

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• 作者：Tymish Y. Ohulchanskyy ; Indrajit Roy ; Lalit N. Goswami ; Yihui Chen ; Earl J. Bergey ; Ravindra K. Pandey ; Allan R. Oseroff ; Paras N. Prasad
• 刊名：Nano Letters
• 出版年：2007
• 出版时间：September 2007
• 年：2007
• 卷：7
• 期：9
• 页码：2835 - 2842
• 全文大小：428K
• 年卷期：v.7,no.9(September 2007)
• ISSN：1530-6992

文摘

We report a novel nanoformulation of a photosensitizer (PS), for photodynamic therapy (PDT) of cancer, where the PS molecules are covalentlyincorporated into organically modified silica (ORMOSIL) nanoparticles. We found that the covalently incorporated PS molecules retained theirspectroscopic and functional properties and could robustly generate cytotoxic singlet oxygen molecules upon photoirradiation. The synthesizednanoparticles are of ultralow size (~20 nm) and are highly monodispersed and stable in aqueous suspension. The advantage offered by thiscovalently linked nanofabrication is that the drug is not released during systemic circulation, which is often a problem with physicalencapsulation. These nanoparticles are also avidly uptaken by tumor cells in vitro and demonstrate phototoxic action, thereby highlightingtheir potential in diagnosis and PDT of cancer.