Crystal and Molecular Structure and Stability of Isoniazid Cocrystals with Selected Carboxylic Acids

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• 作者：Inese Sarcevica ; Liana Orola ; Mikelis V.Veidis ; Anton Podjava ; Sergey Belyakov
• 刊名：Crystal Growth & Design
• 出版年：2013
• 出版时间：March 6, 2013
• 年：2013
• 卷：13
• 期：3
• 页码：1082-1090
• 全文大小：395K
• 年卷期：v.13,no.3(March 6, 2013)
• ISSN：1528-7505

文摘

Reaction of isoniazid with benzoic acid, sebacic acid, suberic acid, and cinnamic acid results in formation of cocrystals. Two polymorphs of isoniazid鈥搒uberic acid and two polymorphs of isoniazid鈥揷innamic acid cocrystals were isolated. Crystal structure analysis shows the presence of a pyridine鈥揷arboxylic acid synthon in the studied cocrystals. The hydrazide group of isoniazid participates in N鈥揌路路路O and N鈥揌路路路N hydrogen bond formation, producing different supramolecular synthons. The stability study of isoniazid cocrystals has been performed over a 22 week period. A comparison of melting points of isoniazid鈥揹icarboxylic acid 2:1 cocrystals shows the decrease of melting point with an increasing length of the acid. Solubility of isoniazid鈥揷arboxylic acid cocrystals tends to increase with increasing solubility of the acid.