Influence of Pendant Arms Bearing Ligating Groups on the Structure of Bismuth Porphyrins: Implications for Labeling Immunoglobulins Used in Medical Applications

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• 作者：Zakaria Halime ; Lydie Michaudet ; Mohammed Lachkar ; Pierre Brossier ; and Bernard Boitrel
• 刊名：Bioconjugate Chemistry
• 出版年：2004
• 出版时间：November 2004
• 年：2004
• 卷：15
• 期：6
• 页码：1193 - 1200
• 全文大小：355K
• 年卷期：v.15,no.6(November 2004)
• ISSN：1520-4812

文摘

The synthesis of two picket bismuth(III) porphyrins is reported, and their crystal structures arecompared. The influence of the nature of the pickets, as well as their number, is discussed in termsof stability, kinetics of metalation, structure, and distortion of the porphyrin. Unexpectedly, the resultsindicate that the coordination sphere of bismuth is not affected by different types of distortion nor isthe stability of the complex. For both types of complexes, the X-ray crystallography revealed that asingle arm is actually in direct interaction with the bismuth cation, thereby allowing furtherfunctionalization on the porphyrin core as the linkage with immunoglobulins or anti-rabbit antibodies(both noted IgG), which have been used in diagnostic or therapeutic applications.