Generalization of Ionic Partition Diagrams to Lipophilic Compounds and to Biphasic Systems with Variable Phase Volume Ratios

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• 作者：Vé ; ronique Gobry ; Sorina Ulmeanu ; Fré ; dé ; ric Reymond ; Gé ; raldine Bouchard ; Pierre-Alain Carrupt ; Bernard Testa ; and Hubert H. Girault
• 刊名：Journal of the American Chemical Society
• 出版年：2001
• 出版时间：October 31, 2001
• 年：2001
• 卷：123
• 期：43
• 页码：10684 - 10690
• 全文大小：129K
• 年卷期：v.123,no.43(October 31, 2001)
• ISSN：1520-5126

文摘

The ionic partition diagram methodology has been generalized to address both hydrophilic andlipophilic compounds and to consider biphasic systems with variable phase volume ratios. With this generalizedapproach electrochemical measurements of ion transfer potentials afford the determination of the standardpartition coefficients of all forms of ionizable molecules, including the neutral form, as well as the evaluationof the dissociation constant of monoprotic substances. An interesting consequence of this approach is thedefinition of an extraction pK_a,ext which is the apparent pK_a of neutral acids and bases when dissolved in theorganic phase.