Stochastic On-Chip Detection of Subpicomolar Concentrations of Silver Nanoparticles

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• 作者：Kay J. Krause ; Alexey Yakushenko ; Bernhard Wolfrum
• 刊名：Analytical Chemistry
• 出版年：2015
• 出版时间：July 21, 2015
• 年：2015
• 卷：87
• 期：14
• 页码：7321-7325
• 全文大小：297K
• ISSN：1520-6882

文摘

We introduce the stochastic amperometric detection of silver nanoparticles on-chip using a microelectrode array. The technique combines the advantages of parallel and low-noise recordings at individually addressable microelectrodes. We demonstrate the detection of subpicomolar concentrations of silver nanoparticles with a diameter of 10 nm at sampling rates in the kilohertz regime for each channel. By comparison to random walk simulations, we show that the sensitivity of a single measurement is mainly limited by adsorption of nanoparticles at the surface of the chips and the measurement time.