An Investigation of the Hydrogen-Bond Preferences and Co-crystallization Behavior of Three Didonor Compounds.
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- 作者：Andreas Lemmerer ; Daniel A. Adsmond ; Joel Bernstein
- 刊名：Crystal Growth & Design
- 出版年：2011
- 出版时间：May 4, 2011
- 年：2011
- 卷：11
- 期：5
- 页码：2011-2019
- 全文大小：1015K
- 年卷期：v.11,no.5(May 4, 2011)
- ISSN：1528-7505
文摘
We assess the suitability of the three didonor compounds as building blocks for ternary co-crystals of the type (didonor)(monoacceptor)2. A Cambridge Structural Database (CSD) survey was carried out to analyze the hydrogen-bond connectivity and develop a strategy for the preparation of the desired co-crystal. Six specific compounds were selected and crystals were grown from 1:1 and 1:2 solutions of didonor compounds (m-hydroxybenzoic acid, p-hydroxybenzoic acid, and racemic mandelic acid) and acceptor compounds (acridine, triphenylphosphine oxide, and nicotinamide) leading to three co-crystals (m-hydroxybenzoic acid)路(triphenylphosphine oxide)2 (1), ((RS)-mandelic acid)路(acridine) (2) and (p-hydroxybenzoic acid)路(nicotinamide) (3). Characterization by single-crystal structure determination confirms the success of this design strategy.