DNA-Directed Synthesis of Aniline and 4-Aminobiphenyl Oligomers: Programmed Transfer of Sequence Information to a Conjoined Polymer Nanowire
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- 作者：Bhaskar Datta ; Gary B. Schuster
- 刊名：Journal of the American Chemical Society
- 出版年：2008
- 出版时间：March 12, 2008
- 年：2008
- 卷：130
- 期：10
- 页码：2965 - 2973
- 全文大小：212K
- 年卷期：v.130,no.10(March 12, 2008)
- ISSN：1520-5126
文摘
A new class of materials was prepared from aniline-containing oligomers that are covalentlylinked to the nucleobases of duplex DNA. Oligomers composed of repeating aniline (PANI) or 4-aminobiphenyl (PAB) units having the properties of conducting polymers conjoined to the DNA were prepared bythe reaction of horseradish peroxidase and H2O2 with DNA having the appropriate monomers aligned withinthe major groove. These oligomers exhibit the spectral and chemical properties typical of para-linkedpolyanilines. This method of preparation enables utilization of the unique self-recognizing properties andsequence programmability of DNA to create tailored oligomers. This ability was demonstrated experimentallyby preparation of PAB oligomers from alternating benzene and aniline monomers. Conjoined conductingpolymers carrying the sequence information of DNA may have applicability as nanowires.