Expedient Preparation of Nazlinine and a Small Library of Indole Alkaloids Using Flow Electrochemistry as an Enabling Technology

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• 作者：Mikhail A. Kabeshov ; Biagia Musio ; Philip R. D. Murray ; Duncan L. Browne ; Steven V. Ley
• 刊名：Organic Letters
• 出版年：2014
• 出版时间：September 5, 2014
• 年：2014
• 卷：16
• 期：17
• 页码：4618-4621
• 全文大小：377K
• ISSN：1523-7052

文摘

An expedient synthesis of the indole alkaloid nazlinine is reported. Judicious choice of flow electrochemistry as an enabling technology has permitted the rapid generation of a small library of unnatural relatives of this biologically active molecule. Furthermore, by conducting the key electrochemical Shono oxidation in a flow cell, the loading of electrolyte can be significantly reduced to 20 mol % while maintaining a stable, broadly applicable process.