Diterpenoids from Croton laui and Their Cytotoxic and Antimicrobial Activities

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• 作者：Cui-Ping Liu ; Jin-Biao Xu ; Jin-Xin Zhao ; Cheng-Hui Xu ; Lei Dong ; Jian Ding ; Jian-Min Yue
• 刊名：Journal of Natural Products
• 出版年：2014
• 出版时间：April 25, 2014
• 年：2014
• 卷：77
• 期：4
• 页码：1013-1020
• 全文大小：340K
• 年卷期：v.77,no.4(April 25, 2014)
• ISSN：1520-6025

文摘

Fourteen new diterpenoids including clerodane (1鈥?b>12), labdane (13), and norlabdane (14) types, as well as nine known analogues were isolated from the aerial parts of Croton laui. Their structures were established on the basis of spectroscopic analysis, and that of crotonolide H (11) was confirmed by single-crystal X-ray crystallography. Crotonolide A (1) exhibited moderate cytotoxicity against two tumor cell lines, HL-60 (human premyelocytic leukemia, IC₅₀ 9.42 渭M) and P-388 (murine leukemia, IC₅₀ 7.45 渭M), and crotonolide G (10) displayed significant antibacterial activity against a panel of Gram-positive bacteria.