Palladium-Catalyzed C鈥揘 Cross Coupling of Sulfinamides and Aryl Halides

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• 作者：Xiaofei Sun ; Xingzhao Tu ; Chuan Dai ; Xiaoping Zhang ; Binbin Zhang ; Qingle Zeng
• 刊名：The Journal of Organic Chemistry
• 出版年：2012
• 出版时间：May 4, 2012
• 年：2012
• 卷：77
• 期：9
• 页码：4454-4459
• 全文大小：239K
• 年卷期：v.77,no.9(May 4, 2012)
• ISSN：1520-6904

文摘

The palladium-catalyzed C鈥揘 cross coupling of sulfinamides and aryl halides is reported. In the presence of Pd₂(dba)₃, tBuXPhos, NaOH, and a small amount of water, the C鈥揘 cross coupling of chiral tert-butanesulfinamide and aryl halides was accomplished to give N-aryl tert-butanesulfinamide without racemization, and the coupling of racemic p-toluenesulfinamide smoothly afforded N-aryl p-toluenesulfinamides. 2-Bromopyridine was also suitable for the coupling. Addition of a small amount of water to the catalytic system was of importance to obtain high yields.