Chemical Molecule-Induced Light-Activated System for Anticancer and Antifungal Activities
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- 作者：Huanxiang Yuan ; Hui Chong ; Bing Wang ; Chunlei Zhu ; Libing Liu ; Qiong Yang ; Fengting Lv ; Shu Wang
- 刊名：The Journal of the American Chemical Society
- 出版年：2012
- 出版时间：August 15, 2012
- 年：2012
- 卷：134
- 期：32
- 页码：13184-13187
- 全文大小：319K
- 年卷期：v.134,no.32(August 15, 2012)
- ISSN：1520-5126
文摘
Except for chemotherapy, surgery, and radiotherapy, photodynamic therapy (PDT) as new therapy modality is already in wide clinic use for the treatment of various diseases. The major bottleneck of this technique is the requirement of outer light source, which always limits effective application of PDT to the lesions in deeper tissue. Here, we first report a new modality for treating cancer and microbial infections, which is activated by chemical molecules instead of outer light irradiation. In this system, in situ bioluminescence of luminol can be absorbed by a cationic oligo(p-phenylene vinylene) (OPV) that acts as the photosensitizer through bioluminescence resonance energy transfer (BRET) process. The excited OPV sensitizes oxygen molecule in the surroundings to produce reactive oxygen species (ROS) that kill the adjacent cancer cells in vitro and in vivo, and pathogenic microbes. By avoiding the use of light irradiation, this work opens a new therapy modality to tumor and pathogen infections.