Development of a Scaleable Synthesis of NDT 9533750, a Key Intermediate to a Series of Novel Subtype Preferring GABAA Partial Agonists

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• 作者：Yuelian Xu ; Bingsong Han ; Zhe-Qing Wang ; Kenneth R. Shaw ; Bertrand L. Chenard ; George Maynard ; Linghong Xie
• 刊名：Organic Process Research & Development
• 出版年：2007
• 出版时间：July 2007
• 年：2007
• 卷：11
• 期：4
• 页码：716 - 720
• 全文大小：109K
• 年卷期：v.11,no.4(July 2007)
• ISSN：1520-586X

文摘

A scaleable route to 6-chloro-4-[2-(3-fluoropyridin-2-yl)-imidazol-1-ylmethyl]-5-propyl-pyrimidine (NDT 9533750), a keyintermediate to a series of novel subtype preferring GABA_Apartial agonists, is described in which various scaleup issueswere addressed to provide an efficient and robust route for thepreparation of kilogram quantities of the compound.