Transition Metal-Free Direct C鈥揌 Functionalization of Quinones and Naphthoquinones with Diaryliodonium Salts: Synthesis of Aryl Naphthoquinones as 尾-Secretase Inhibitors

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• 作者：Dawei Wang ; Bingyang Ge ; Liang Li ; Jie Shan ; Yuqiang Ding
• 刊名：Journal of Organic Chemistry
• 出版年：2014
• 出版时间：September 19, 2014
• 年：2014
• 卷：79
• 期：18
• 页码：8607-8613
• 全文大小：487K
• ISSN：1520-6904

文摘

A novel ligand-free, transition metal-free direct C鈥揌 functionalization of quinones with diaryliodonium salts has been developed for the first time. The transformation was promoted only through the use of a base and gave aryl quinone derivatives in moderate to good yields. This methodology provided an effective and easy way to synthesize 尾-secretase inhibitors. The radical trapping experiments showed that this progress was the radical mechanism.