An Efficient Method for Construction of the Angularly Fused 6,3,5-Tricyclic Skeleton of Mycorrhizin A and Its Analogues

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• 作者：Binxun Yu ; Tuo Jiang ; Weiguo Quan ; Junpeng Li ; Xinfu Pan ; Xuegong She
• 刊名：Organic Letters
• 出版年：2009
• 出版时间：February 5, 2009
• 年：2009
• 卷：11
• 期：3
• 页码：629-632
• 全文大小：143K
• 年卷期：v.11,no.3(February 5, 2009)
• ISSN：1523-7052

文摘

The angularly fused 6,3,5-tricyclic system is readily generated via a cascade cyclization under acid promotion. The reaction proceeds at room temperature with high stereochemical fidelity from the electrophilic center of the epoxide to the cyclopropane product. This methodology provides a potentially useful approach for the synthesis of mycorrhizin A and its analogues.