Microwave-Assisted Synthesis of Biocompatible Europium-Doped Calcium Hydroxyapatite and Fluoroapatite Luminescent Nanospindles Functionalized with Poly(acrylic acid)

详细信息    查看全文

• 作者：Alberto Escudero ; Mauricio E. Calvo ; Sara Rivera-Fern谩ndez ; Jes煤s M. de la Fuente ; Manuel Oca帽a
• 刊名：Langmuir
• 出版年：2013
• 出版时间：February 12, 2013
• 年：2013
• 卷：29
• 期：6
• 页码：1985-1994
• 全文大小：590K
• 年卷期：v.29,no.6(February 12, 2013)
• ISSN：1520-5827

文摘

Europium-doped calcium hydroxyapatite and fluoroapatite nanophosphors functionalized with poly(acrylic acid) (PAA) have been synthesized through a one-pot microwave-assisted hydrothermal method from aqueous basic solutions containing calcium nitrate, sodium phosphate monobasic, and PAA, as well as sodium fluoride in the case of the fluoroapatite particles. In both cases a spindlelike morphology was obtained, resulting from an aggregation process of smaller subunits which also gave rise to high specific surface area. The size of the nanospindles was 191 (32) 脳 40 (5) nm for calcium hydroxyapatite and 152 (24) 脳 38 (6) nm for calcium fluoroapatite. The luminescent nanoparticles showed the typical red luminescence of Eu³⁺, which was more efficient for the fluoroapatite particles than for the hydroxyapatite. This is attributed to the presence of OH^{鈥?/sup> quenchers in the latter. The nanophosphors showed negligible toxicity for Vero cells. Both PAA-functionalized nanophosphors showed a very high (up to at least 1 week) colloidal stability in 2-(N-morpholino)ethanesulfonic acid (MES) at pH 6.5, which is a commonly used buffer for physiological pH. All these features make both kinds of apatite-based nanoparticles promising tools for biomedical applications, such as luminescent biolabels and tracking devices in drug delivery systems.}