Reaction of a Copper(II)鈥揘itrosyl Complex with Hydrogen Peroxide: Phenol Ring Nitration through a Putative Peroxynitrite Intermediate

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• 作者：Apurba Kalita ; Ramesh C. Deka ; Biplab Mondal
• 刊名：Inorganic Chemistry
• 出版年：2013
• 出版时间：October 7, 2013
• 年：2013
• 卷：52
• 期：19
• 页码：10897-10903
• 全文大小：379K
• 年卷期：v.52,no.19(October 7, 2013)
• ISSN：1520-510X

文摘

Copper(II) complex, 1, with the histidine-derived ligand L (L = methyl 2-(2-hydroxybenzylamino)-3-(1H-imidazol-5-yl)propanoate) has been synthesized and characterized. Single-crystal structure determination reveals a diphenolato-bridged dicopper(II) core in 1. Addition of ^{鈥?/sup>NO to an acetonitrile solution of 1 affords the corresponding mononuclear copper(II)鈥搉itrosyl complex, 2. In the presence of H₂O₂, 2 results in formation of the corresponding copper(I)鈥損eroxynitrite. Formation of peroxynitrite (鈭?/sup>OONO) intermediate is evident from its characteristic phenol ring nitration reaction which resembles the tyrosine nitration in biological systems. Further, isolation of nitrate (NO₃鈥?/sup>) as the decomposition product from 2 at room temperature also supports the involvement of 鈥?/sup>OONO intermediate.}