Lipase-Catalyzed Ring-Opening Polymerization of the O-Carboxylic Anhydride Derived from Lactic Acid

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• 作者：Colin Bonduelle ; Blanca Martin-Vaca ; Didier Bourissou
• 刊名：Biomacromolecules
• 出版年：2009
• 出版时间：November 9, 2009
• 年：2009
• 卷：10
• 期：11
• 页码：3069-3073
• 全文大小：170K
• 年卷期：v.10,no.11(November 9, 2009)
• ISSN：1526-4602

文摘

Both lipase PS and Novozym 435 promote the ring-opening polymerization of lacOCA, the O-carboxylic anhydride derived from lactic acid. Accordingly, PLA of relatively high molecular weights (M_n up to 38400 g/mol) and low polydispersities (M_w/M_n < 1.4) are obtained in high yields within a few hours at 80 °C. Slight preference for l-lacOCA over d-lacOCA is observed, and with Novozym 435, the molecular weight of the obtained PLA can be controlled by varying the lipase loading.