An Interrupted Fischer Indolization Approach toward Fused Indoline-Containing Natural Products

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• 作者：Ben W. Boal ; Alex W. Schammel ; Neil K. Garg
• 刊名：Organic Letters
• 出版年：2009
• 出版时间：August 6, 2009
• 年：2009
• 卷：11
• 期：15
• 页码：3458-3461
• 全文大小：231K
• 年卷期：v.11,no.15(August 6, 2009)
• ISSN：1523-7052

文摘

An efficient method to access the fused indoline ring system present in a multitude of bioactive molecules has been developed. The strategy involves the condensation of hydrazines with latent aldehydes to ultimately deliver indoline-containing products by way of an interrupted Fischer indolization sequence. Our studies show that the approach will likely be amenable to the synthesis of complex targets, such as the communesin natural products.