In Situ Generation of Phosphoryl Alkylindiums and Their Synthetic Application to Arylalkyl Phosphonates via Palladium-Catalyzed Cross-Coupling Reactions
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- 作者：Sanghyuck Kim ; Cheol-Eui Kim ; Boram Seo ; Phil Ho Lee
- 刊名：Organic Letters
- 出版年：2014
- 出版时间：November 7, 2014
- 年：2014
- 卷：16
- 期：21
- 页码：5552-5555
- 全文大小：348K
- ISSN：1523-7052
文摘
Phosphoryl alkylindium reagents are generated in situ from the direct insertion of indium with bromoalkyl phosphonates in the presence of CuCl, and their synthetic application to arylalkyl phosphonates is reported via a Pd-catalyzed cross-coupling reaction with tolerance of a diversity of functional groups including ester, ketone, aldehyde, nitrile, nitro, trifluoromethyl, chloride, methoxy, hydroxy, and amino.