General Route to Racemic and Enantiomeric Carbo- and Heterocyclic Vinyl Sulfoxides via Tandem Michael Addition/Horner Olefination of pubs.acs.org/images/gifchars/alpha.gif" border="0"

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• 作者：Marian Miko//pubs.acs.org/images/entities/lstrok.gif" border="0">ajczyk ; Jerzy A. Krysiak ; Wanda H. Midura ; Micha//pubs.acs.org/images/entities/lstrok.gif" border="0"> W.
• 刊名：Journal of Organic Chemistry
• 出版年：2006
• 出版时间：November 10, 2006
• 年：2006
• 卷：71
• 期：23
• 页码：8818 - 8823
• 全文大小：126K
• 年卷期：v.71,no.23(November 10, 2006)
• ISSN：1520-6904

文摘

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A new one-pot synthesis of heterocyclic and carbocyclic vinyl sulfoxides has been developed whichinvolves reaction of gifchars/alpha.gif" BORDER=0>-phosphorylvinyl sulfoxides with carbonyl compounds bearing oxygen, nitrogen,and carbon nucleophilic centers. Use of optically active gifchars/alpha.gif" BORDER=0>-phosphorylvinyl p-tolyl sulfoxides in this tandemMichael addition/Horner olefination reaction leads to the corresponding optically active cyclic sulfoxides.In this way, a variety of optically active chromene, pyrrolizine, chinoline, and cyclopentene sulfoxideshave been efficiently prepared.