Redox and Electrocatalytic Properties of Mimochrome VI, a Synthetic Heme Peptide Adsorbed on Gold
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- 作者：Antonio Ranieri ; Stefano Monari ; Marco Sola ; Marco Borsari ; Gianantonio Battistuzzi ; Paola Ringhieri ; Flavia Nastri ; Vincenzo Pavone ; Angelina Lombardi
- 刊名：Langmuir
- 出版年：2010
- 出版时间：December 7, 2010
- 年：2010
- 卷：26
- 期：23
- 页码：17831-17835
- 全文大小：801K
- 年卷期：v.26,no.23(December 7, 2010)
- ISSN：1520-5827
文摘
Mimochrome VI (MC-VI) is a synthetic heme peptide containing a helix−heme−helix sandwich motif designed to reproduce the catalytic activity of heme oxidases. The thermodynamics of Fe(III) to Fe(II) reduction and the kinetics of the electron-transfer process for MC-VI immobilized through hydrophobic interactions on a gold electrode coated with a nonpolar SAM of decane-1-thiol have been determined through cyclic voltammetry. Immobilization slightly affects the reduction potential of MC-VI, which under these conditions electrocatalytically turns over molecular oxygen. This work sets the premise for the exploitation of totally synthetic mimochrome-modified electrode surfaces for clinical and pharmaceutical biosensing.