Synthesis of a Functionalizable Water-Soluble Cryptophane-111

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• 作者：Emmanuelle Dubost ; Naoko Kotera ; S茅bastien Garcia-Argote ; Yves Boulard ; Estelle L茅once ; C茅line Boutin ; Patrick Berthault ; Christophe Dugave ; Bernard Rousseau
• 刊名：Organic Letters
• 出版年：2013
• 出版时间：June 7, 2013
• 年：2013
• 卷：15
• 期：11
• 页码：2866-2868
• 全文大小：227K
• 年卷期：v.15,no.11(June 7, 2013)
• ISSN：1523-7052

文摘

The development of optimized xenon host systems is of crucial importance for the success of molecular imaging using hyperpolarized ¹²⁹Xe MRI. Cryptophane-111 is a promising candidate because of its encapsulation properties. The synthesis of cryptophane-111-based biosensors requires both water-solubilizing and chemically activatable groups. An expeditious synthesis of a water-soluble and functionalizable cryptophane-111 is described.