Nucleophilic Substitution of Azide Acting as a Pseudo Leaving Group: One-Step Synthesis of Various Aza Heterocycles

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• 作者：Christelle Doebelin ; Martine Schmitt ; Cyril Antheaume ; Jean-Jacques Bourguignon ; Fr茅d茅ric Bihel
• 刊名：Journal of Organic Chemistry
• 出版年：2013
• 出版时间：November 15, 2013
• 年：2013
• 卷：78
• 期：22
• 页码：11335-11341
• 全文大小：387K
• 年卷期：v.78,no.22(November 15, 2013)
• ISSN：1520-6904

文摘

The reaction of 3-azidopropanoic acid with the carbodiimide-based coupling reagent DIC leads to a six-membered-ring intermediate acting as a versatile precursor to a diverse set of aza heterocycles, including mono-, bi-, and tricyclic compounds.