Access to 4-Alkylaminopyridazine Derivatives via Nitrogen-Assisted Regioselective Pd-Catalyzed Reactions
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- 作者：Emilie Blaise ; Arthur E. K眉mmerle ; Hassan Hammoud ; Jo茫o Xavier de Ara煤jo-J煤nior ; Fr茅d茅ric Bihel ; Jean-Jacques Bourguignon ; Martine Schmitt
- 刊名：Journal of Organic Chemistry
- 出版年：2014
- 出版时间：November 7, 2014
- 年：2014
- 卷：79
- 期：21
- 页码：10311-10322
- 全文大小：509K
- ISSN：1520-6904
文摘
3-Substituted, 6-substituted, and unsymmetrical 3,6-disubstituted 4-alkylaminopyridazines were prepared from a sequence of three chemo- and regioselective reactions combining amination and palladium-catalyzed cross-coupling reactions, such as reductive dehalogenation and Suzuki鈥揗iyaura reactions. Extension of the methodology to Sonogashira reaction yielded a novel class of 3-substituted pyrrolopyridazines.