Bioavailability and Antioxidant Effects of a Xanthone-Rich Mangosteen (Garcinia mangostana) Product in Humans

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• 作者：Miwako Kondo ; Liliang Zhang ; Hongping Ji ; Yan Kou ; Boxin Ou
• 刊名：Journal of Agricultural and Food Chemistry
• 出版年：2009
• 出版时间：October 14, 2009
• 年：2009
• 卷：57
• 期：19
• 页码：8788-8792
• 全文大小：789K
• 年卷期：v.57,no.19(October 14, 2009)
• ISSN：1520-5118

文摘

Oxidative damage is involved in many chronic diseases including those cited as the major causes of death in Western societies such as cardiovascular disorders and cancer. Antioxidants may prevent these degenerative processes by various mechanisms including the scavenging of free radicals. Intake of antioxidant supplements is associated with preventing oxidative damages. This study investigated the absorption and antioxidant effects of a xanthone-rich mangosteen liquid in healthy human volunteers after the acute consumption of 59 mL of the supplement. The liquid contained mangosteen, aloe vera, green tea, and multivitamins. Results indicated that α-mangostin and vitamins B₂ and B₅ were bioavailable, with observed C_max at t_max of around 1 h. The antioxidant capacity measured with the oxygen radical absorbance capacity (ORAC) assay was increased with a maximum effect of 18% after 2 h, and the increased antioxidant level lasted at least 4 h. Overall, this study demonstrated the bioavailability of antioxidants from a xanthone-rich mangosteen product and its in vivo antioxidant effects.