Selective Sequence for the Peptide-Triggered Phase Transition of Lyotropic Liquid-Crystalline Structures

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• 作者：Qingtao Liu ; Yao-Da Dong ; Ben J. Boyd
• 刊名：Langmuir
• 出版年：2016
• 出版时间：May 24, 2016
• 年：2016
• 卷：32
• 期：20
• 页码：5155-5161
• 全文大小：555K
• 年卷期：0
• ISSN：1520-5827

文摘

A novel concept of using mixed lipids to construct selective peptide-sequence-sensing lyotropic liquid-crystalline (LLC) dispersion systems was investigated. The LLC systems were constructed using a mixture of phytantriol, a lipid that forms lyotropic liquid-crystalline phases, and a novel synthesized peptide–lipid (peplipid) for sensing a target peptide with the RARAR sequence. The internal structure of the dispersed LLC particles was converted from the lamellar structure (liposomes) to the inverse bicontinuous cubic phase (cubosomes) in the presence of the target peptide. The addition of common human proteins did not induce any structural change, indicating a high selectivity of interaction with the target peptide. The concept has potential for the design of targeted controlled release drug delivery agents.