Evidence for Age-Dependent in Vivo Conformational Rearrangement within A尾 Amyloid Deposits
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- 作者：Sofie Nystr枚m ; Katarzyna M. Psonka-Antonczyk ; P氓l Gunnar Ellingsen ; Leif B. G. Johansson ; Nina Reitan ; Susann Handrick ; Stefan Prokop ; Frank L. Heppner ; Bettina M. Wegenast-Braun ; Mathias Jucker ; Mikael Lindgren ; Bj酶rn Torger Stokke ; Per Hammarstr枚m ; K. Peter R. Nilsson
- 刊名：ACS Chemical Biology
- 出版年：2013
- 出版时间：June 21, 2013
- 年：2013
- 卷：8
- 期：6
- 页码：1128-1133
- 全文大小：389K
- 年卷期：v.8,no.6(June 21, 2013)
- ISSN：1554-8937
文摘
Deposition of aggregated A尾 peptide in the brain is one of the major hallmarks of Alzheimer鈥檚 disease. Using a combination of two structurally different, but related, hypersensitive fluorescent amyloid markers, LCOs, reporting on separate ultrastructural elements, we show that conformational rearrangement occurs within A尾 plaques of transgenic mouse models as the animals age. This important mechanistic insight should aid the design and evaluation of experiments currently using plaque load as readout.