Synthesis of Enantioenriched Homopropargylic Sulfonamides by a Three Component Reaction of Aldehydes, Sulfonamides, and Chiral Allenylsilanes

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• 作者：Ryan A. Brawn ; James S. Panek
• 刊名：Organic Letters
• 出版年：2009
• 出版时间：October 1, 2009
• 年：2009
• 卷：11
• 期：19
• 页码：4362-4365
• 全文大小：212K
• 年卷期：v.11,no.19(October 1, 2009)
• ISSN：1523-7052

文摘

Enantioenriched allenylsilanes are used as carbon nucleophiles in three-component reactions with in situ generated N-sulfonylimines to selectively form syn-homopropargylic sulfonamides. The reactions proceed with a variety of aldehyde and sulfonamide reaction partners. These novel reaction products are obtained with useful levels of diastereoselectivity, and the axial chirality of the allenylsilane is fully transferred to point chirality, forming products with >97% ee.