Gold-Catalyzed Three-Component Coupling: Oxidative Oxyarylation of Alkenes
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- 作者：Asa D. Melhado ; William E. Brenzovich ; Jr. ; Aaron D. Lackner ; F. Dean Toste
- 刊名：Journal of the American Chemical Society
- 出版年：2010
- 出版时间：July 7, 2010
- 年：2010
- 卷：132
- 期：26
- 页码：8885-8887
- 全文大小：259K
- 年卷期：v.132,no.26(July 7, 2010)
- ISSN：1520-5126
文摘
The three-component coupling of terminal alkenes with arylboronic acids and oxygen nucleophiles is described. The reaction employs a binuclear gold(I) bromide as a catalyst and Selectfluor reagent as the stoichiometric oxidant. Alcohols, carboxylic acids, and water can be employed as oxygen nucleophiles, thus providing an efficient entry into β-aryl ethers, esters, and alcohols from alkenes.