Me3(OMe)tBuXPhos: A Surrogate Ligand for Me4tBuXPhos in Palladium-Catalyzed C鈥揘 and C鈥揙 Bond-Forming Reactions

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• 作者：Satoshi Ueda ; Siraj Ali ; Brett P. Fors ; Stephen L. Buchwald
• 刊名：The Journal of Organic Chemistry
• 出版年：2012
• 出版时间：March 2, 2012
• 年：2012
• 卷：77
• 期：5
• 页码：2543-2547
• 全文大小：305K
• 年卷期：v.77,no.5(March 2, 2012)
• ISSN：1520-6904

文摘

A new biarylphosphine ligand, Me₃(OMe)tBuXPhos (L3), was designed as a surrogate for Me₄tBuXPhos (L1). The Me₃(OMe)tBuXPhos could be prepared in a chromatography-free manner from inexpensive and readily available 2,3,6-trimethylphenol. Comparative studies demonstrated that a catalyst based on Me₃(OMe)tBuXPhos displayed the same reactivity as a catalyst based on Me₄tBuXPhos for Pd-catalyzed C鈥揘 and C鈥揙 bond-forming processes.