Palladium-Catalyzed Synthesis of N-Aryl Carbamates

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• 作者：Ekaterina V. Vinogradova ; Nathaniel H. Park ; Brett P. Fors ; Stephen L. Buchwald
• 刊名：Organic Letters
• 出版年：2013
• 出版时间：March 15, 2013
• 年：2013
• 卷：15
• 期：6
• 页码：1394-1397
• 全文大小：273K
• 年卷期：v.15,no.6(March 15, 2013)
• ISSN：1523-7052

文摘

An efficient synthesis of aryl carbamates was achieved by introducing alcohols into the reaction of palladium-catalyzed cross-coupling of ArX (X = Cl, OTf) with sodium cyanate. The use of aryl triflates as electrophilic components in this transformation allowed for an expanded substrate scope for direct synthesis of aryl isocyanates. This methodology provides direct access to major carbamate protecting groups, S-thiocarbamates, and diisocyanate precursors to polyurethane materials.