Interfacial pH: A Critical Factor for Osteoporotic Bone Regeneration
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- 作者：Yuhui Shen ; Waiching Liu ; Kaili Lin ; Haobo Pan ; Brian W. Darvell ; Songlin Peng ; Chunyi Wen ; Lianfu Deng ; William W. Lu ; Jiang Chang
- 刊名：Langmuir
- 出版年：2011
- 出版时间：March 15, 2011
- 年：2011
- 卷：27
- 期：6
- 页码：2701-2708
- 全文大小：1192K
- 年卷期：v.27,no.6(March 15, 2011)
- ISSN：1520-5827
文摘
Osteoporosis is a disease attributed to an imbalance in communication between osteoblasts and osteoclasts, possibly arising from a locally acidic microenvironment which hinders normal cell function. However, to date, little or no attention has been paid to these cells鈥?milieu in respect of implant materials. Although it has been claimed for a few biomaterials that they stimulate bone formation, seldom has their surface behavior been invoked to explain behavior. With degradation, ion concentrations and pH at the material鈥檚 surface must vary and thus may affect osteoblast response directly. On degradation of a recently developed biomaterial, Sr-containing CaSiO3, the interfacial pH was found to be appreciably higher than that of the bulk medium and the 鈥渟tandard鈥?physiological value of 7.4. At these high values (pH > 8), both the proliferation and alkaline phosphatase (ALP) activity of osteoblasts was significantly enhanced, with a maximum response at 10% Sr substitution for Ca. This shows that the chemistry of the solid鈭抣iquid interface is a critical factor in bone regeneration, although this has generally been overlooked. Thus, the interfacial pH in particular is to be considered, rather than the bulk value, and this may be of importance in many related contexts in bone-tissue engineering.