Redox-Switchable Surface for Controlling Peptide Structure

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• 作者：Brian M. Lamb ; Muhammad N. Yousaf
• 刊名：Journal of the American Chemical Society
• 出版年：2011
• 出版时间：June 15, 2011
• 年：2011
• 卷：133
• 期：23
• 页码：8870-8873
• 全文大小：780K
• 年卷期：v.133,no.23(June 15, 2011)
• ISSN：1520-5126

文摘

A general surface chemistry strategy is described for the development of a new switchable material. The method modulates a surface-immobilized-molecules structure by using two orthogonal 鈥渃lick鈥?reactions based on Huisgen cycloaddition and oxime chemistry, where the oxime linkage is redox active and switchable. We demonstrate this strategy by developing a noninvasive, biocompatible, in situ surface chemistry that is able to modulate the affinity of a cell-adhesive peptide to cell integrin receptors to study dynamic cell adhesion and cell migration in real time and as a new hide-and-reveal strategy for application in new types of smart biofouling biomaterials.