Total Synthesis of (+)-Fastigiatine

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• 作者：Brian B. Liau ; Matthew D. Shair
• 刊名：Journal of the American Chemical Society
• 出版年：2010
• 出版时间：July 21, 2010
• 年：2010
• 卷：132
• 期：28
• 页码：9594-9595
• 全文大小：182K
• 年卷期：v.132,no.28(July 21, 2010)
• ISSN：1520-5126

文摘

The first total synthesis of the Lycopodium alkaloid (+)-fastigiatine has been accomplished in 15 steps and 30% overall yield from known compounds. Noteworthy transformations include a convergent fragment coupling via a nucleophilic cyclopropane opening, a highly diastereoselective formal [3 + 3]-cycloaddition, and a transannular Mannich reaction to construct the core of the natural product.