Structure, Absolute Configuration, and Antidiarrheal Activity of a Thymol Derivative from Ageratina cylindrica
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- 作者：Celia Bustos-Brito ; Mariano S谩nchez-Castellanos ; Baldomero Esquivel ; Jos茅 S. Calder贸n ; Fernando Calzada ; Lilian Yepez-Mulia ; Angelina Hern谩ndez-Barrag谩n ; Pedro Joseph-Nathan ; Gabriel Cuevas ; Leovigildo Quijano
- 刊名：Journal of Natural Products
- 出版年：2014
- 出版时间：February 28, 2014
- 年：2014
- 卷：77
- 期：2
- 页码：358-363
- 全文大小：290K
- 年卷期：v.77,no.2(February 28, 2014)
- ISSN：1520-6025
文摘
The leaves of Ageratina cylindrica afforded a thymol derivative that was characterized by physical and spectroscopical methods as (8S)-8,9-epoxy-6-hydroxy-l0-benzoyloxy-7-oxothymol isobutyrate (1). The absolute configuration of 1 was established as 8S by vibrational circular dichroism spectroscopy in combination with density functional theory calculations and by evaluation of the Flack and Hooft X-ray parameters. Compound 1 showed weak antiprotozoal activity against Entamoeba histolytica and Giardia lamblia trophozoites and a high inhibitory effect on hyperpropulsive movement of the small intestine in rats.